Brain Morphometrics that Provide a Better Understanding of Chiari Type I Malformation


Summer Biomechanics, Bioengineering and Biotransport Conference

Introduction Excerpt

Through examination of MR images, additional brain and cranial structures have been shown to differ significantly between CMI patients and healthy individuals. In previous studies, a reduced posterior cranial fossa (PCF) is the principal attribute of CMI [3]. Yet, other studies did not find a relationship between PCF area and CMI [4].

The main objective for this study was to determine additional parameters aside from TP that differentiate between CMI patients and healthy controls, with the potential to improve diagnosis and prognosis of this disorder. A subset of these parameters located within the PCF compartment will be discussed within this abstract..


Maggie S. Eppelheimer, James R. Houston, Soroush H. Pahlavian, Audrey M. Braun, Dipankar Biswas, Dorothy M. Loth, Aintzane Urbizu, Richard Labuda, Philip A. Allen, Francis Loth